|Awarded On||February 15, 2023|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Lu Wang|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
|Summary of Goals and Objectives||
Hepatocellular carcinoma (HCC) accounts for 90% of liver cancer cases, the fourth leading cause of cancer-related mortality worldwide. A higher incidence of HCC is observed in the Hispanic population, the largest demographic group in South Texas. More than two-thirds of all new cancers are diagnosed among individuals aged 60 years and older. Age is the primary risk factor for adult cancer and non-alcoholic steatohepatitis (NASH), a precursor for HCC. As such, elucidating how aging contributes to NASH and HCC risk will provide biomarkers for early detection and guide the development of novel prevention and treatment regimens. Epigenetic alteration is a hallmark of aging and cancer. The drugga...