|Awarded On||February 15, 2023|
|Title||Recruitment of Established Investigators|
|Award Mechanism||Recruitment of Established Investigators|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Rudi Fasan|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Natural products have represented a prominent source of cancer drugs and valuable chemical probes for investigating cancer-associated biological processes. The structural complexity of these molecules, however, constitute a major hurdle toward their expeditious synthesis and manipulation, as required for their development into probes and therapeutics. Building upon our pioneering contributions in the development of chemo-enzymatic strategies for late-stage functionalization and diversification of complex natural products, this project will generate large libraries of novel and unique natural-product-like compounds as a readily accessible source of small-molecule agents for both basic cancer ...