|Awarded On||November 16, 2022|
|Title||Recruitment of Established Investigators|
|Award Mechanism||Recruitment of Established Investigators|
|Institution/Organization||The Methodist Hospital Research Institute|
|Principal Investigator/Program Director||Keith Chan|
|Cancer Sites||Bladder, Pancreas, Skin|
|Summary of Goals and Objectives||
My goal at Houston Methodist (HM) is to strategically integrate basic/translational research efforts in the Department of Urology and Neal Cancer Center to expedite innovative investigator-initiated clinical trials (IITs) to benefit cancer patients and build training reputation in GU Oncology. Building on my current research and training momentum, this CPRIT Award will propel the following objectives: 1) Leverage HM’s extraordinary clinical infrastructure to translate discoveries into IITs. 1a) Plan and initiate a proof-of-concept Phase 1 clinical trial of iDAMP blockade as an innovative approach to enhance chemoimmunotherapy response in bladder cancer patients, filling a major clinical gap ...