|Awarded On||November 18, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jihan Osborne|
|Cancer Sites||Kidney and Renal Pelvis, Lung and Bronchus|
|Summary of Goals and Objectives||
Cancer stem cells (CSCs) contribute to intra-tumor heterogeneity by providing the tumor with cells that can differentiate and de-differentiate according to the stress of the environment. CSC utilize many of the same developmental pathways used by normal stem/progenitor cells during embryogenesis, including those for energy consumption, increased proliferation, overcoming hypoxic conditions, and inducing migration. The RNA binding protein, Lin28 and the microRNA, (miRNA) let-7 are part of an evolutionarily conserved developmental feedback loop that acts as a heterochronic regulator of developmental timing in metazoans from worms to m...