Grant ID RR210013
Awarded On November 18, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Jeanine Van Nostrand
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $2,000,000
Summary of Goals and Objectives

Metabolic deregulation, largely associated with loss of the energy stress sensor AMPK, has become appreciated as a significant risk factor for hepatocellular carcinoma (HCC). HCC is a deadly cancer with very few effective treatments for the advance stages and is increasingly prevalent in Texas, in part due to a high rate of obesity and non-alcoholic fatty liver disease. The high incidence and mortality rates of patients with HCC emphasize the necessity for both understanding the etiology of HCC and developing preventative therapeutics against HCC.

While previous studies have uncovered a correlative role for AMPK activation in HCC, neither the functional role of AMPK in HCC prevention nor the...

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