|Awarded On||November 18, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Furqan Fazal|
|Summary of Goals and Objectives||
Dysregulated RNA processing is a common hallmark of cancer, with somatic mutations frequently targeting regulators of RNA splicing, localization, and decay. Indeed, a major mechanism governing RNA translation and function is through regulated RNA subcellular localization, and functional genomics studies have frequently identified regulators of RNA localization as selective cancer dependencies. Yet the role of RNA mislocalization in driving cancer phenotypes is poorly understood, largely because of a lack of tools.
By combining my unique background in computation, biophysics, and technology development, I propose to establish a multidisciplinary cancer research program to systematically char...