Grant ID RR200108
Awarded On August 19, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Andrew Sandstrom
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

Inflammation is a critical immune response that acts to recruit inflammatory cells to sites of infection and initiate protective immune responses; however, chronic inflammation promotes oncogenesis and tumor growth. While the pathogen-associated triggers of inflammation are well characterized, the molecular mechanisms that trigger chronic inflammation in cancer remain unclear. To clarify mechanisms that induce cancer-associated inflammation, I will investigate how activation of the NLRP1 inflammasome contributes to inflammation in cancer. 

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