|Awarded On||August 19, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Hongjie Li|
|Cancer Sites||Colorectal, Small Intestine|
|Summary of Goals and Objectives||
A central goal of my future research is to discover how aging triggers tumor onset in the regenerating intestine. Age-related epithelial tumorigenesis is a complex and dynamic process, consisting of three major stages: initiation, progression, and metastasis. Accumulating evidence suggests that tumor initiation is not only due to cell intrinsic changes, such as age-related accumulated oncogenic mutations, but also can be triggered by tissue microenvironment changes, such as chronic inflammation.
I am interested in identifying the molecular mechanisms of age-related triggering of colorectal cancers by applying state-of-the-art in vivo cell-surface proteomics and single-cell transcriptomic an...