|Awarded On||August 21, 2019|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Benjamin Sabari|
|Cancer Sites||Breast, Prostate, Uterus|
|Summary of Goals and Objectives||
The objective of this proposal is to gain mechanistic insight into the role of Mediator-dependent condensate formation in ER+ breast cancer. The MED1 subunit of the Mediator complex is required for ER gene regulation, tumor formation, and resistance to therapy. I showed that MED1 forms phase-separated condensates at sites of gene activation.
My hypothesis is that MED1 is required for estrogen-dependent gene activation because of its capacity to form condensates at ER target genes. Dissecting the molecular mechanism of MED1 phase separation promises to reveal new regulatory mechanisms with the potential to uncover novel avenues ...