Grant ID RR190046
Awarded On May 15, 2019
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Rice University
Principal Investigator/Program Director Yang Gao
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

Genome replication and maintenance play fundamental roles in both tumorigenesis and cancer treatment. The overarching goals of my research are to investigate the molecular mechanisms of genome replication and maintenance processes, how they work under normal and stress conditions, how their abnormalities lead to mutations, genome rearrangements and cancer, and how they selectively protect cancer genome integrity during cancer treatment.

In the immediate future, my laboratory will focus on pathways within mitochondria, which employ distinct proteins for genome replication and maintenance and play important roles during cancer development and progression. A deep understanding of mitochondria g...

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