RR180056 — Cancer Prevention and Research Institute of Texas

Grant Information

Grant ID	RR180056
Awarded On	August 24, 2018
Title	Recruitment of Established Investigators
Program	CPRIT Scholar
Award Mechanism	Recruitment of Established Investigators
Institution/Organization	The University of Texas Southwestern Medical Center
Principal Investigator/Program Director	Anke Henning
Cancer Sites	Brain and Other Nervous System
Contracted Amount	$6,000,000
Summary of Goals and Objectives	Multi-modal 7T MRI for Personalized Treatment of Glioblastoma Multiforme Primary Objective: • Establish improved diagnostic criteria for management of brain tumor patients in a personalized manner utilizing multi-modal ultra-high field MRI and machine learning. Specific problems to overcome are the inability of current diagnostic standards for: prognostics and patient stratification with regard to the choice of the optimal treatment unambiguous therapy response monitoring under different forms of treatment image-guided radiation therapy and surgery spinal cord tumor management. Specific Goals: • explore potential of ultra-hig... Read More Multi-modal 7T MRI for Personalised Treatment of Glioblastoma Multiforme Primary Objective: Establish improved diagnostic criteria for management of brain tumor patients in a personalized manner utilizing multi-modal ultra-high field MRI and machine learning. Specific problems to overcome are the inability of current diagnostic standards for: prognostics and patient stratification with regard to the choice of the optimal treatment option unambiguous therapy response monitoring under different forms of treatment image-guided radiation therapy and surgery spinal cord tumor management. Specific Goals: Explore potential of ultra-high field and cutting-edge MRI to enable high-quality structural, functional and metabolic imaging of the human brain and spinal cord at 7T, Compare advantages of 7T versus 3T MRI with regard to sensitivity and specificity of diagnostic brain cancer imaging given higher signal-to-noise and contrast-to-noise ratios and thus spatial resolution in structural and functional imaging, Exploit added value of metabolic imaging contrasts available at 7T, which reflect tumor proliferation, immune response, Warburg effect, and genetic subtypes for clinical decision making in brain cancer due to higher signal-to-noise ratio and spectral resolution, Use multi-modal 7T MRI to reveal potential biomarkers for diagnostics, patient stratifications, therapy monitoring and image-guided therapy in patients with brain and spinal cord cancer Read Less