|Awarded On||February 15, 2023|
|Title||Targeting the Mlc1-GlialCAM Protein Complex in Invasive Glioma Cells|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Joseph McCarty|
|Cancer Sites||Brain and Other Nervous System|
Glioblastoma (GBM) is a malignant brain cancer that is refractory to standard surgical, radiation, and chemotherapeutic interventions. The average survival for patients after diagnosis is less than two years, and this has improved little in the past few decades. Hence, a better understanding of the basic cellular and molecular events that contribute to GBM initiation and progression may lead to new therapeutic strategies to benefit patients. We have discovered a new pathway in GBM cells, comprised of the Mlc1 and GlialCAM proteins, that plays important roles in promoting tumor cell invasive growth. In this project we will develop strategies to target the Mlc1-GlialCAM pathway using pre-clini...