|Awarded On||February 15, 2023|
|Title||Whole Genome DNA Methylation Markers for Tracking and Predicting Advanced Liver Fibrosis as a Precursor of Liver Cancer in NAFLD.|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Robert Tsai|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
There is a disproportionately high number of liver cancer patients in the Mexican American population in south Texas due to a high prevalence of fatty liver diseases, which affect 1 in 5 adults in Texas and 1 in 3 of its Hispanic population. Individuals with fatty liver are at risk for progressing to liver cancer through an intermediary step of liver fibrosis. The existence of a large liver cancer at-risk population in Texas provides an opportunity to develop and implement strategies to prevent liver cancer that will have major health impacts. There is an unmet need for new screening tools that are easily applicable in the clinic and capable of identifying individuals with fatty liver diseas...