|Awarded On||September 14, 2022|
|Title||Targeting Tumors and the Tumor Microenvironment with Banana Lectin Expressing T cells|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Katie McKenna|
|Cancer Sites||Lung and Bronchus|
Recent developments in the treatment of blood cancers with a genetically enhanced cell therapy called CAR T cells have improved patient outcomes. Unfortunately, those same therapies have not had the same success for solid cancers, which are much more common. Here we propose therapies to target not only the cancer cells in solid tumors but also the normal cells surrounding the cancer cells that act as their support structure and help the tumor grow. These surrounding cells also protect the tumor from the immune system and prevent some treatments from reaching and killing the cancer cells. By targeting both cell types, our proposed therapy should increase anti-tumor activity of drugs and cell ...