Grant ID RP220292
Awarded On February 16, 2022
Title i-SINFOP: Integrative Systems-scale Interrogation of Neomorphic Fusion OncoProteins
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Nidhi Sahni
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

Gene fusions, encoding fusion oncoproteins, represent an important class of oncogenic driver aberrations which hold great promise clinically for cancer therapy. A great success of personalized cancer therapy is the case of BCR-ABL fusion oncoprotein and the use of gleevec (imatinib) or related compounds. Apart from a few classic examples heavily investigated for decades, the remaining cancer gene fusions have negligible information about their functional consequences. These examples argue that, understanding how gene fusions cause cancer will require parallel systematic platforms characterizing the molecular and mechanistic behaviors of fusion oncoproteins.

To tackle this problem, we propose...

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