Grant ID RP200120
Awarded On February 19, 2020
Title Single-Cell Evaluation to Identify Tumor-stroma Niches Driving the Transition from In Situ to Invasive Breast Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Helen Piwnica-Worms
Cancer Sites Breast
Contracted Amount $900,000
Lay Summary

Ductal carcinoma in situ (DCIS) is a non-invasive tumor lesion of the breast that can advance to become invasive breast cancer (IBC). We do not understand how these lesions progress, nor can we identify which lesions will behave aggressively and progress to invasive cancer. Our research seeks to bridge these knowledge gaps by studying the relationship between DCIS tumor cells and their neighboring non-tumor cells (“stroma”), to better understand how the stroma promotes aggressive disease. Using patient samples and mouse models, we will evaluate tumor-stroma relationships in both early-stage and advanced breast cancer. We will evaluate stromal cells at the single-cell level to document how t...

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