Grant ID RP200023
Awarded On February 19, 2020
Title Off the shelf, Cord-Derived iNK T cells Engineered to Prevent GVHD and Relapse After Hematopoietic Stem Cell Transplantation
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Jin Seon Im
Cancer Sites Leukemia
Contracted Amount $900,000
Lay Summary

Allogeneic stem cell transplantation (ASCT) is only curative treatment for several blood cancer such as leukemia and lymphoma, and works through high dose chemotherapy to eradicate blood cancer in combination of donor immune system fighting against blood cancer. However, it is not offered to every patient who need because of high risk of developing transplant related complication such as Graft-Versus-Host-Disease (GVHD) where donor immune system attacks recipient’s body. Moreover, blood cancer may come back even after transplantation. Thus, an innovative therapy to prevent both GVHD and relapse of blood cancer is needed to improve the success rate of ASCT. Here, we propose to develop a n...

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