|Awarded On||August 21, 2019|
|Title||A novel cellular-level imaging approach to assess payload drug distribution in tumors following administration of targeted drug delivery systems|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Medical Branch at Galveston|
|Principal Investigator/Program Director||Brendan Prideaux|
|Cancer Sites||All Sites|
In order for an anticancer drug to be effective, it must gain access to solid tumors via the blood supply and penetrate the extravascular space to reach all of the cancer cells in sufficient concentration for therapeutic effect. These issues are magnified in the treatment of glioblastoma multiform (GBM) due to the added requirement of the drug to successfully pass the blood brain barrier (BBB). Drug delivery systems in the form of nanoparticles or antibody-drug conjugates, have been developed to address the difficulty in delivering sufficient drug concentrations to all target cells in solid tumors. However, detailed localization of the drug following NP delivery is challenging, as current vi...