Grant ID RP190655
Awarded On August 21, 2019
Title Mechanisms of exosomal cell entry and signaling in cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas Agrilife Research
Principal Investigator/Program Director Jean-Philippe Pellois
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

Exosomes are vesicles secreted by human cells. By allowing the transfer of bioactive molecules between cells, exosomes play an important role in cell-cell communication. In particular, exosomes participate in propagating metastatic signals in cancer. In this project, our central goal is to determine the basic mechanisms by which exosomes transfer signals from metastatic cancer cells to other cells, thereby promoting disease. To pursue this goal, several novel assays that report quantitatively on exosomal cell entry will be developed. We will use these assays to learn how the surface composition of exosomes controls where they go and what they do. These biological ground rules of exosomal fun...

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