Grant ID RP190653
Awarded On August 21, 2019
Title Nanosized immunotherapies to access and treat pediatric medulloblastoma
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Jennifer Maynard
Cancer Sites Brain and Other Nervous System
Contracted Amount $200,000
Lay Summary

Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor in children with no long-term cure. Current therapies rely on radiation which provides only a brief respite from disease. Even when temporarily successful, the therapies themselves cause significant damage to healthy brain tissue. A significant unmet need is development of effective therapies that can be delivered non-invasively, are non-toxic for non-tumor tissues and do not cause inflammation within the central nervous system. We aim to generate a multi-functional antibody able to penetrate the blood-brain barrier and starve DIPG cells of essential nutrients. Cancer cells are notable for their rapid growth, which must...

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