Grant ID RP190556
Awarded On August 21, 2019
Title Targeting ARNT and RBFOX2 alternative splicing as a novel treatment modality in lymphoid malignancies
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Medical Branch at Galveston
Principal Investigator/Program Director Casey W Wright
Cancer Sites Leukemia, Lymphoma
Contracted Amount $200,000
Lay Summary

Non-Hodgkin lymphoma (NHL) includes a number of aggressive T and B cell lymphomas that predominantly affect children. For example, anaplastic large cell lymphoma is a peripheral T-NHL that constitutes 40% of NHL in children. Similarly, Burkitt lymphoma, a B-NHL, accounts for 30% of all childhood lymphoma. Most patients respond well to treatment using standard chemotherapy. However, a majority often relapse and require more intense therapy, putting these patients in jeopardy for developing toxic side effects should the cancer go back into remission. This project aims to test the efficacy of novel splice-switching oligonucleotides in blocking the pro-cancerous functions of specific genes in ly...

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