Grant ID RP190539
Awarded On August 21, 2019
Title Therapeutic Targeting of EWS-FLI1 Turnover in Ewing Sarcoma
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Ralf Kittler
Cancer Sites Sarcoma
Contracted Amount $200,000
Lay Summary

Ewing sarcoma is a cancer that mainly grows in the bones of children and teenagers. If found early, it can be cured with surgery, radiation and chemotherapy, however these treatments have serious side effects in young people, and are often ineffective. We propose to lay the groundwork for a new therapy that has less side effects, and could also be effective when the standard treatment fails. Our proposed strategy may achieve that by developing a drug that decreases the amount of a protein, EWS-FLI1 that is only produced by Ewing sarcoma cells, and essential for these cancer cells to grow and survive. We previously found that ERG, a protein very similar to the FLI1 part of EWS-FLI1, is stabil...

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