Grant ID RP190435
Awarded On February 21, 2019
Title Modulating Cardiomyocyte DNA Damage in Response to Genotoxic Stress
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Hesham Sadek
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

Chest radiotherapy and systemic chemotherapy are the effective treatment modalities for numerous types of cancers, including Hodgkin lymphoma and bone cancers among others. Unfortunately, cancer therapeutics have significant deleterious effects on the heart that are far more pronounced in patients receiving the therapy at younger age. One of the most serious, and poorly understood side effects is the delayed effect of cancer therapeutics on the heart muscle. Epidemiological studies indicate that the majority of patients undergoing chest radiotherapy during adolescence and young adulthood develop fibrosis in the cardiac muscle and are six times more likely to develop heart failure. Similarly,...

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