Grant ID RP190417
Awarded On February 21, 2019
Title Decoding the Pathogenic Roles of Noncoding Variants in Hematopoietic Malignancies
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jian Xu
Cancer Sites Leukemia
Contracted Amount $900,000
Lay Summary

Acute myeloid leukemia (AML) accounts for 90% of acute leukemias in adult and 15-20% of those in children. AML is a genetically heterogeneous blood cancer associated with a variety of genomic alterations. The discovery of recurrent mutations in protein-coding genes has provided successful targets for diagnosis, prognosis and therapies; however, it remains elusive how alterations within non-coding DNA sequences, consisting of 98.5% of human genome, contribute to AML development. The challenge is twofold: 1) to establish causality of non-coding mutations, and 2) to distinguish oncogenic non-coding drivers from non-functional genetic variants. Enhancers are non-coding DNA sequences that determi...

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