Grant ID RP190366
Awarded On August 21, 2019
Title Characterization and optimization of novel allosteric KRAS inhibitors
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Alemayehu Gorfe
Cancer Sites Colorectal, Pancreas, Small Intestine
Contracted Amount $897,483
Lay Summary

The National Cancer Institute estimates that there will be 1,735,350 new cases of cancer in 2018 in the US. Activating mutations of a key enzyme in humans, called KRAS, are known to occur in about 20% of all human cancers. Combining these two statistics, we estimate that about 350,000 US residents will be affected by one or another form of KRAS-related cancers per year. Currently, there are no drugs that can directly act on mutated KRAS to stop its cancer-causing activities. As a result, KRAS-related cancers, which include some of the deadliest, such as pancreatic cancer, remain untreatable. Clearly, anti-KRAS medications would save millions of lives. Supported by a previous CPRIT grant, we...

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