Grant ID RP190049
Awarded On February 21, 2019
Title Noninvasive Detection and Assessment of Therapy Response in Multiple Myeloma Using Whole-Body MRI
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Ananth J Madhuranthakam
Cancer Sites Myeloma
Contracted Amount $1,189,577
Lay Summary

Multiple Myeloma (MM) is the second most common hematologic malignancy in the United States. MM originates in the bone marrow and eventually creates bone lesions, occurring in ~60% of patients at diagnosis, and in all patients over the course of the disease. It results in severe bone pain, hypercalcemia, and spinal cord compression leading to pathologic fractures or paralysis. Whole-body X-ray is currently used to identify bone lesions, however, they are most often detected only at advanced stages. The International Myeloma Working Group (IMWG) now recommends whole-body magnetic resonance imaging (WBMRI) as the preferred imaging technique for pretreatment assessment. However, MRI is most of...

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