Grant ID RP190043
Awarded On February 21, 2019
Title Mitochondrial Metabolism and RNA Methylation in Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Ricardo Aguiar
Cancer Sites Leukemia, Lymphoma
Contracted Amount $900,000
Lay Summary

Epigenetic deregulations are those that lead to change in gene levels without altering the genetic code. Epigenetic remodeling is an integral part of cancer initiation, maintenance and progression. DNA methylation is the most studied epigenetic change. However, recent evidence suggests that RNA methylation is as important as DNA methylation to human physiology and pathology, including cancer. RNA methylation is tightly controlled by the abundance and activity of proteins that promote it (RNA methyltransferase) and those that terminate it (RNA demethylases). We discovered that a ubiquitous cancer promoting gene, MYC, is a critical regulator of RNA methylation. Our data suggest that MYC induce...

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