Grant ID RP190012
Awarded On February 21, 2019
Title Berberine in Prevention of Biochemical Recurrence
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Addanki Kumar
Cancer Sites Prostate
Contracted Amount $900,000
Lay Summary

Radiation (RT) and androgen deprivation (ADT) are important modalities for the treatment of patients diagnosed with early localized and advanced metastatic PCa respectively. These approaches (i) ultimately lead to resistance and recurrent cancer and (ii) are associated with side effects that impact quality of life significantly. We propose that “downregulation of ribosomal protein S6 (p70S6K encoded by RPS6KB1)” will be effective in preventing recurrence. This premise is based on our observations that (i) human prostate tumors show significantly elevated levels of p70S6K and (ii) genetic and pharmacologic inhibition of RPS6KB1 enhances the effectiveness of radiation in PCa cells. We hypothes...

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