Grant ID RP180846
Awarded On August 24, 2018
Title Molecular Opening of the Blood-Brain Barrier by Molecular Hyperthermia
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Zhenpeng Qin
Cancer Sites Brain and Other Nervous System
Contracted Amount $200,000
Lay Summary

Glioblastoma, the most common primary adult brain tumor, is among the most lethal of all solid tumors with a median survival of 14.6 months, which has remained unchanged for over a decade despite intense therapeutic efforts. A unique and major unmet challenge of treating brain tumor is difficulty of delivering effective drugs across the blood-brain barrier (BBB). Our long-term goal is develop an effective strategy to transiently increase BBB permeability that will permit effective delivery of antineoplastic drugs. The specific goal of this project is to design and synthesize light absorbing nanoparticles that target endothelial cell tight junction associated proteins, which form a critica...

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