Grant ID RP180844
Awarded On August 24, 2018
Title Regulating Androgen Receptor as a Corepressor by Neurofibromin (NF1)
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Eric Chang
Cancer Sites Breast
Contracted Amount $200,000
Lay Summary

To treat a given cancer patient with just the right medicine, we must thoroughly understand the molecular factors driving the disease. This project centers on the NF1 gene, the loss of which was first discovered to cause neurofibromatosis type-1, the world's most common hereditary genetic disorder affecting 1 in every 3,000 births. Patients with this disease often develop disfiguring neuronal tissue outgrowth, and have higher propensities for acquiring malignant diseases. We now know that NF1 can also be lost later in life in a wide range of common cancers, such as cancer of the breast, skin, central nervous system, ovaries, etc. Thus, NF1 is a critical tumor suppressor whose normal func...

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