Grant ID RP180826
Awarded On August 24, 2018
Title Integrative Analysis of Structural Variants in Cancer Genomes
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jian Xu
Cancer Sites Leukemia
Contracted Amount $200,000
Lay Summary

Acute myeloid leukemia (AML) accounts for 90% of all acute leukemias in adults and 15-20% of those in children. AML is a genetically heterogeneous blood cancer and its disease development is associated with a variety of genomic structural variants (SVs) such as chromosomal translocations, large sequence insertions and deletions. The discovery of recurrent AML-associated SVs has provided successful targets for diagnosis, prognosis and therapeutics; however, due to major limitations of conventional SV detection tools, recurrent SVs were not identified or characterized in the majority of AML cases. This represents a major challenge in risk stratification and clinical management of these patient...

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