Grant ID RP180812
Awarded On August 24, 2018
Title Fluorescently Labeled Somatostatin Analogs for Image-Guided Surgery in Neuroendocrine Tumors
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Ali Azhdarinia
Cancer Sites Lung and Bronchus, Pancreas, Small Intestine
Contracted Amount $200,000
Lay Summary

Cancer surgery is the foundation for curative therapy and has major therapeutic implications for patients with neuroendocrine tumors (NETs). Unlike most cancers, surgery is performed in NETs even if metastases are present in order to control excessive hormone production that could further stimulate tumor growth. In NETs, surgery is often complicated by difficulties in identifying small liver metastases, which give rise to remarkably high recurrence rates. Accordingly, the goal of this project is to develop a contrast agent that improves intraoperative detection of NETs and increases overall survival. Radiolabeled peptides are widely used in the clinic for NET imaging before and after surgery...

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