Grant ID RP180810
Awarded On August 24, 2018
Title Controlling the Activity of Anticancer T Cells by Inducing Replicative Senescence
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Maksim Mamonkin
Cancer Sites Leukemia, Lymphoma
Contracted Amount $200,000
Lay Summary

Certain cancers can be effectively treated — and even cured — by enhancing cells from a patient’s own body. Changing these specialized immune cells, called “T cells,” to enable them recognize and kill tumor cells has a number of advantages over conventional cancer drugs. For instance, T cells can easily find tumors, multiply and remain in the body until the tumor is cleared. One downside to these powerful “living drugs” is that their long-term activity in patients hard to control or even predict, which sometimes results in unwanted toxicities. For example, T cells trained to recognize leukemia cells also attack normal blood cells responsible for preventing infections, among other functions. ...

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