Grant ID RP180804
Awarded On August 24, 2018
Title Protein Array and Analysis Core (PAAC)
Program Academic Research
Award Mechanism Core Facility Support Awards
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Mark Bedford
Cancer Sites All Sites
Contracted Amount $2,594,107
Lay Summary

A protein is a chain of amino acids. During protein synthesis, 20 different amino acids can be incorporated into a protein, which then folds to form a structure that will dictate its function in cells. Once synthesized, a protein can undergo further chemical modification to alter its cellular function through a process called posttranslational modification (PTM). PTMs can either alter the structure of a protein or generate a docking site for a binding protein. We are particularly interested in identifying and characterizing protein interactions that are driven by PTMs. Processes that regulate PTMs in normal cells become deregulated in cancer cells through altered functions of the enzymes tha...

Read More