Grant ID RP180801
Awarded On August 24, 2018
Title Targeting the Menopause Transition to Decrease the Risk for Obesity-Associated Postmenopausal Breast Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas Agrilife Research
Principal Investigator/Program Director Erin Giles
Cancer Sites Breast
Contracted Amount $200,000
Lay Summary

Women who are overweight or obese have an increased risk for developing breast cancer after menopause. There are suggestions that an inexpensive, FDA-approved drug used to treat diabetes (called metformin) may also help decrease the risk of developing breast cancer in women who are overweight/obese, or those with diabetes. Using an animal model, we have shown that weight gain during menopause, combined with pre-existing obesity, increases tumor development and growth. We have further shown that treating these same animals with metformin long-term can decrease this breast cancer risk. In this grant, our goal is to determine whether we can specifically target metformin to a narrow window of ti...

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