Grant ID RP180770
Awarded On August 24, 2018
Title Preclinical Radiation Core Facility (PCRCF)
Program Academic Research
Award Mechanism Core Facility Support Awards
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Debabrata Saha
Cancer Sites All Sites
Contracted Amount $3,723,260
Lay Summary

More than 50% of cancer patients are treated by radiation therapy with curative intent. Pre-clinical radiation research performed using cell or small animal models, is important for understanding radiobiological mechanisms and developing new radiotherapeutic strategies that combine immunotherapy or targeted agents, as examples. Unfortunately, and a concern of the federal health agencies, is the fact that many investigators do not have the proper foundation in physics and radiobiology to properly use this technology. Experimental devices are often improperly calibrated and radiation doses are poorly calculated. Errors of >20% are often observed, which is in stark contrast to human RT where...

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