Grant ID RP180700
Awarded On August 24, 2018
Title Mechanisms of Drug Resistance in Lung Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Neal Alto
Cancer Sites Lung and Bronchus
Contracted Amount $200,000
Lay Summary

The future of cancer research lies in a personalization of medicine, where each patient’s treatment regime is tailored to the unique genetic makeup of their tumor. However, tumor resistance to chemotherapy continues to be a major threat to personalized medicine as the underlying mechanisms of drug resistance are often unclear. In addition, the identification of biomarkers that predict drug resistance in patients remains a major future challenge. This proposal investigates a potentially new mechanism of cancer cell resistance to a promising new class of chemotherapeutics, collectively termed “Smac-mimetics”. These small molecules kill tumor cells by initiating an inflammatory type of c...

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