Grant ID RP180505
Awarded On February 21, 2018
Title Circulating Exosomes as Biomarkers for Lung Cancer Early Detection
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Samir Hanash
Cancer Sites Lung and Bronchus
Contracted Amount $799,085
Lay Summary

Lung cancer is the leading cause of cancer death among men, and the second leading cause among women worldwide. Lung cancer screening with low-dose computed tomography (LDCT) has been shown to reduce mortality by 20%, although there are concerns including high false positivity, cost, and radiation exposure. Of note, the false positive rate of lung cancer screening with LDCT alone was 96.4%. Blood-based biomarkers are a promising and attractive approach to complement LDCT. We identified and have undertaken initial validation studies of a set of circulating lung cancer biomarkers, while we have recently developed high-yield and high-purity methods for isolation of circulating exosomes, which h...

Read More