Grant ID RP180463
Awarded On February 21, 2018
Title Compound heterozygous mutations in pediatric cancer predisposition
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Katharina Schlacher
Cancer Sites Head and Neck, Leukemia, Vagina
Contracted Amount $556,763
Lay Summary

Understanding the underlying causes for pediatric cancer is instrumental in guiding prediction and treatment strategies to reduce the suffering of our children. Fanconi Anemia is a disease that affects children at a young age. Typically, it first presents itself as anemia, but also may include short stature and skin abnormalities. Most prominently, even after treatment of the anemia by bone marrow transplantation, these children develop cancer, in particular leukemia, head and neck and gynecological cancers. Biologically, genes with mutations that lead to Fanconi Anemia are important for the repair of a specific type of DNA damage, a DNA interstrand cross link. However, we recently have ide...

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