Grant ID RP180457
Awarded On February 21, 2018
Title Tumor Activated Enzyme Inhibitors for the Treatment of Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Joseph M Ready
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct, Lung and Bronchus
Contracted Amount $607,830
Lay Summary

Ideal treatments for cancers kill tumor cells but not normal tissues. Traditional chemotherapies do not meet this ideal because they injure both cancer cells and normal cells. Agents like cisplatin help shrink tumors but cause peripheral pain due to toxicity to nerve tissues. Similarly, many chemotherapies cause nausea because they damage the stomach and intestines. The poor selectivity of traditional therapies not only causes debilitating side effects. It also reduces the effectiveness of drugs because it limits the tolerable dose. In this application, we describe technology that can limit the systemic toxicity of cancer treatments. We discovered that certain cancer types express metaboli...

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