Grant ID RP180435
Awarded On February 21, 2018
Title Fasting-induced inhibition of leukemia development
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Chengcheng Zhang
Cancer Sites Leukemia
Contracted Amount $900,000
Lay Summary

Acute lymphoblastic leukemia (ALL), which includes B cell and T cell subtypes (B-ALL and T-ALL), is the most common form of cancer in children and also occurs in adults. Although treatment of pediatric ALL is highly effective, a sizeable number of patients are non-responders. The prognosis for adult ALL patients is significantly worse than for pediatric ALL patients. Additionally, some types of ALL have a much poorer prognosis than others. New therapeutic targets and approaches are needed to effectively treat ALL. Using mouse tumor models, we demonstrated that fasting alone robustly inhibits the development of both B-ALL and T-ALL, but not acute myeloid leukemia (AML). Mechanistically, we fo...

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