Grant ID RP180343
Awarded On February 21, 2018
Title Turn ON the Tumor Contrast in Lymph Node Metastases for Occult Disease Detection
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jinming Gao
Cancer Sites Breast, Head and Neck
Contracted Amount $885,684
Lay Summary

Lymph node metastasis (LNM) is the most important determinant factor for survival for many solid cancers. The gold standard for detection of regional metastatic disease from most cancers is a regional nodal dissection and histologic examination by a trained pathologist. This can result in significant morbidity including shoulder dysfunction and pain in head and neck patients, and lymphedema, pain and impaired arm use in breast cancer patients. Sentinel lymph node biopsy is an alternative surgical staging method. However, small but significant false negative rates limit its clinical use. The objective of this application is to establish pH threshold sensors to detect occult lymph node metasta...

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