Grant ID RP180319
Awarded On February 21, 2018
Title Rhabdomyosarcoma vulnerabilities: Prioritizing and extending to the clinic
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Stephen X Skapek
Cancer Sites Sarcoma
Contracted Amount $1,193,363
Lay Summary

Survival for children with certain types of cancer remains dismal despite many years of research. This is particularly true for children with rhabdomyosarcoma, the most common soft tissue sarcoma in children. Only about 1 in 5 children with metastatic or recurrent disease survive for three years, and this poor outlook has not improved despite many attempts to intensify chemotherapy and use new agents. Many experts feel that new insight into rhabdomyosarcoma biology is needed to light a path toward better therapy. Toward this goal, advances in DNA sequencing and computational analysis tools have enabled detailed studies of DNA within rhabdomyosarcoma, and much of that work has focused on ide...

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