Grant ID RP180196
Awarded On February 21, 2018
Title Microwafers as Novel Drug or Gene Delivery Vehicles for Noninvasive Treatment of Retinoblastoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Richard Hurwitz
Cancer Sites Eye and Orbit
Contracted Amount $1,195,721
Lay Summary

We have developed novel, non-invasive microwafers that can deliver nanoparticles (small beads) containing drugs to tissues or tumors. We hypothesize that this system would be ideal for treating retinoblastoma. Retinoblastoma, an ocular cancer that occurs in young children, can affect one or both eyes. Removal of the eye (enucleation) with the tumor is often curative but ophthalmologists are opting for local therapies to control small tumors or systemic chemotherapy to control larger tumors with the goal of saving vision. Sometimes small pieces of tumor break off to form vitreous seeds. There is no good option other than enucleation for this condition. The development of alternative treatment...

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