Grant ID RP170734
Awarded On August 16, 2017
Title Mitochondrial DNA Instability Engages a Cancer-Related Interferon Program to Modify the Immune Microenvironment and NAD+ Metabolome and Enhance Melanoma Growth
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University System Health Science Center
Principal Investigator/Program Director Andrew West
Cancer Sites Skin
Contracted Amount $199,795
Lay Summary

Malignant melanoma is a cancer of specialized skin pigment cells called melanocytes. The incidence of malignant melanoma continues to rise more rapidly than all other malignancies except lung cancer. Although early-stage melanoma can be cured by surgical excision of malignant tissue, the five-year survival rate for patients with advanced melanoma is roughly 39 percent, indicating the aggressive and lethal nature of this disease. Recently, immunotherapies that promote anti-tumor immune responses have opened promising avenues for late stage treatment, and a better understanding of the factors that influence the tumor immune environment will support more effective therapies. Mitochondria are c...

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