Grant ID RP170714
Awarded On August 16, 2017
Title Optimization of a Novel Class of Microtubule Stabilizers That Circumvent Multiple Drug Resistance Mechanisms Through Crystal-Structure Guided Total Synthesis
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at San Antonio
Principal Investigator/Program Director Douglas Frantz
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

For more than 70 years, Nature has provided some of the most important medicines to combat cancer. A recent study in 2016 showed that of the 175 drugs approved to treat cancer since the 1940’s, 85, or 49%, were actually natural products or direct derivatives. Natural products are chemical compounds produced by organisms as part of their normal daily fight for survival. With respect to cancer, most of these life-saving medicines including paclitaxel, vinblastine, etoposide, camptothecin and topotecan have been derived from various plant sources. Thus, the discovery and development of plant-derived natural products to identify new cancer treatments remains an important avenue of basic research...

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