Grant ID RP170686
Awarded On August 16, 2017
Title A Novel Chemical Strategy to Target EGFR for Destruction
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Hai Rao
Cancer Sites Breast, Lung and Bronchus, Thyroid
Contracted Amount $200,000
Lay Summary

Resistance arises when tumors often adapt to the drug and manage to find alternate routes to resume cell growth. Selective proteolysis of a key regulator allows for rapid adjustments of its concentration and has emerged as a promising therapeutic means for cancer. The goal of this work is to develop a novel approach to modulate protein stability that would eliminate, rather than simply inhibit, the target protein, which would overcome drug resistance, a common shortcoming of targeted therapies. Specifically, we will design and evaluate novel cell permeable compounds that exploit the cell’s own proteasome-mediated degradation pathway to specifically eliminate the epidermal growth factor rece...

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