Grant ID RP170644
Awarded On August 16, 2017
Title Establish a New Cryo-Electron Microscopy Core Facility and Service for Structure Determination at UT Southwestern Medical Center
Program Academic Research
Award Mechanism Core Facility Support Awards
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Daniela Nicastro
Cancer Sites All Sites
Contracted Amount $5,498,714
Lay Summary

Understanding the causes of cancer and identifying treatments for this devastating disease require knowledge of the cellular machineries (protein complexes) that are the drivers of tumor initiation, progression and metastasis. Determining the three-dimensional structures of these machineries is essential to understanding the mechanisms of cancer, identifying drug targets and developing therapeutics. Recent revolutionary advances have rendered cryo-electron microscopy (cryo-EM) the method of choice for determining protein structures in detail, i.e. at the level of individual atoms; while cryo-electron tomography (cryo-ET) enables these molecular machines to be viewed inside cells. UT Southwes...

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