Grant ID RP170572
Awarded On August 16, 2017
Title Probing Novel Concepts of the NF-kappaB Transcriptional Program in Human Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Ivan D'Orso
Cancer Sites All Sites
Contracted Amount $679,458
Lay Summary

Normal cells produce master transcriptional regulators that control key biological processes. The genetic inactivation of these factors and the processes that control their activity promote cancer development. One of these transcriptional regulators is NF-kB, which modulates the synthesis of a vast array of genes that control inflammation and cell survival. Deregulated NF-kB activation (oncogenic addiction) leads to chronic inflammation and uncontrolled cell growth (both cancer drivers). Thus, selective inhibition of the NF-kB pathway to induce cell death has emerged as a rational therapeutic approach to combat cancer. To date, however, no clear unique mechanism exists to target cancer cells...

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