Grant ID RP170510
Awarded On November 16, 2016
Title Telomere Maintenance Mechanisms in Neuroblastoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization Texas Tech University Health Sciences Center
Principal Investigator/Program Director Charles Reynolds
Cancer Sites Brain and Other Nervous System
Contracted Amount $1,058,246
Lay Summary

Neuroblastoma is childhood cancer that can spontaneously regress without therapy or relentlessly progress in spite of intensive chemotherapy. For continual cell growth cancer cells must maintain the ends of chromosomes (called telomeres) which erode if not maintained by telomere maintenance mechanisms (TMM). The most common TMM uses an enzyme in cells called telomerase which is capable of adding DNA to the ends of chromosomes. Some cancers use a non-telomerase mechanism known as alternate lengthening of telomeres (ALT). Low-risk wide-spread neuroblastomas (known as stage 4S) can spontaneously regress without therapy; some stage 4S neuroblastomas progress and kill the patient. In collabor...

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